The Science of Energy: Why Mitochondrial Health Matters

Modern daily life demands a tremendous amount from our bodies, yet the microscopic engines driving our daily stamina are frequently overlooked: our mitochondria.

These microscopic structures—frequently called the “powerhouses of the cell”—produce ATP (adenosine triphosphate), the cellular currency that supports essential functions throughout the body, including daily energy, metabolic balance, and physical resilience. Research supported by the National Institutes of Health (NIH) highlights how fundamental mitochondrial activity is to overall well-being.

Maintaining mitochondrial health through everyday lifestyle choices is an effective way to preserve long-term energy, stamina, and recovery.

Mitochondria: A Core Part of Cellular Health

Mitochondria convert nutrients from food into usable energy through a process called oxidative phosphorylation. When this process functions efficiently, it supports:

  • Steady, sustained daily energy levels
  • Overall metabolic balance
  • Cognitive clarity and focus
  • Physical performance and recovery

When cellular energy production is impacted by factors like everyday stress, inadequate nutrition, or lack of rest, its effects can be felt across the body. Studies link variations in mitochondrial efficiency with changes in daily energy and stamina over time.

NAD+: A Key Molecule in Energy Production

  • A central component of mitochondrial function is NAD+ (nicotinamide adenine dinucleotide), a vital coenzyme involved in:
  • Cellular energy production
  • DNA maintenance processes
  • Core metabolic pathways
  • Active mitochondrial signaling

Within the cells, NAD+ helps transfer electrons during energy metabolism, directly supporting ATP production. Adequate NAD+ levels are an important part of maintaining efficient cellular energy function.

Why NAD+ Levels Change Over Time

NAD+ levels naturally shift over time and can also be influenced by lifestyle factors, daily stress, and habits. This is part of normal biological variation and is associated with:

  • Changes in natural cellular energy production
  • Shifts in everyday physical stamina
  • Metabolic balance adjustments

While cellular energy regulation is complex, supporting healthy daily habits plays a meaningful role in how our cells function and adapt over time.

NAD+, Cellular Function, and Daily Maintenance

Beyond energy production, NAD+ is involved in natural biological pathways related to cellular maintenance and stress response, including:

  • Sirtuins (such as SIRT1 and SIRT3), which help regulate cellular responses to daily stress
  • PGC-1α, which supports the body’s natural cellular renewal pathways
  • Antioxidant systems that help manage everyday oxidative stress

Supporting healthy lifestyle habits that promote NAD+ availability can help maintain efficient cellular function and overall physical vitality.

From Science to Practical Application

Understanding mitochondrial health allows for a more foundational approach to well-being—focusing on supporting the body at the cellular level through consistent daily habits.

Tools like the VELL Health app help translate this science into practical, everyday strategies, including:

  • Nutrition approaches that provide foundational support for cellular energy
  • Lifestyle factors such as optimizing sleep, managing stress, and incorporating daily movement
  • Actionable guidance tailored to support daily wellness

The goal is to make complex biology accessible, actionable, and personalized to your unique routine.

Why This Matters

Health is increasingly viewed through a proactive and personalized lens, with a greater focus on foundational biology. Mitochondrial function is an essential part of that daily conversation.

By prioritizing your body’s energy systems and overall wellness, you can:

  • Support natural, steady energy production throughout the day
  • Maintain everyday cognitive and physical performance
  • Build long-term resilience against everyday stressors
  • Promote comprehensive, whole-body well-being

Health starts at the cellular level. Nurturing these foundational systems creates a strong base for everyday vitality.

Disclaimer: This content is for informational and educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before making significant changes to your diet, exercise, or supplementation routine.

Sources:

  • National Institutes of Health. (n.d.). Mitochondria and health. NIH Research Matters.
  • Waddell, J., et al. (n.d.). Cellular and mitochondrial NAD homeostasis in health and disease. PubMed.
  • Zhao, Y., et al. (n.d.). NAD+ improves cognitive function and reduces neuroinflammation.
  • Srivastava, S. (n.d.). Emerging therapeutic roles for NAD+ metabolism.
  • Yusri, K., Jose, S., Vermeulen, K. S., Tan, T. C. M., & Sorrentino, V. (2025). The role of NAD+ metabolism and its modulation of mitochondria in aging and disease. npj Metabolic Health and Disease, 3(1), 26. 
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Dr. Jack Waterman, DO, FACOI
Board Certifications
  • American Osteopathic Board of Internal Medicine — Internal Medicine
  • American Osteopathic Board of Internal Medicine — Nephrology

Dr. Jack Waterman is a board-certified nephrologist and internal medicine physician with decades of clinical and healthcare leadership experience. He serves on the Jupiter Medical Center Board of Trustees and as Medical Director of the Jupiter Kidney Center. His expertise in kidney health, hypertension and complex chronic disease management brings an important clinical perspective to VELL’s Health Advisory Board.

David A. Lickstein, MD, FACS
Cleveland Clinic Florida

Board Certified Plastic Surgeon, Expert in Liposuction, Cosmetic Breast Implants, Cancer Related Breast Reconstruction, and Skin Cancer Surgery.

Sylvia Zuniga-Barboni, MD, FAAN
Cleveland Clinic Florida
With an esteemed background including fellowships at Cleveland Clinic Florida and expertise in neurology, electrodiagnostic medicine, and botulinum toxin chemodenervation, Dr. Zuniga-Barboni brings a wealth of knowledge to our mission of holistic well-being. Board-certified and re-certified, her commitment to neurological health adds valuable perspectives to our efforts.
Michael Solomon, MD
St. Lucie Surgery Center
Received his Bachelor of Science from Binghamton University in 1988. After receiving his BS degree, he studied at SUNY Health Science Center at Brooklyn where he earned his Doctor of Medicine degree in 1992. Dr. Solomon performed his post graduate training in Urology and General Surgery from 1992-1999 at SUNY Health Science Center at Brooklyn where he served as a Chief Resident in Urology. In addition, he completed a 1 year Urological Oncology Research Fellowship at Memorial Sloan Kettering Cancer Center in NYC from 1995-1996.
Dr. Jordan Zabriskie
Clinic Director at Elite Therapy and Wellness
“Dr Z” graduated from the University of Florida and Palmer College of Chiropractic, with a focus in Sports Medicine . He has successfully treated thousands of patients with a multifaceted approach. Using physical therapy , movement correction , and chiropractic medicine to provide long lasting solutions to their conditions . Dr Z believes educating a patient and empowering them to “ fix “ their own dysfunction is an integral part of their recovery .
Dr. Richard A. DeLucia, Jr., MD, MBA
Board Certified Family Physician
Dr. Richard DeLucia is a Board Certified Family Practice Physician who began his practice in Jupiter in 2000 and is the founder of Jupiter Family Healthcare. He graduated from of the University of Florida College of Medicine and completed his residency training at Carolina’s Medical Center Family Practice Program, in Charlotte, North Carolina in 1998. Dr. DeLucia was the Chief of Family Medicine at Jupiter Medical Center from 2004-2008.
Linda Kiley, MD
Palm Beach Center for Pelvic Health
Linda A. Kiley, MD, is a graduate of University of California at Los Angeles School of Medicine and completed her residency in Obstetrics and Gynecology at the George Washington University in Washington, DC. She is a Board Certified physician and subspecialist in Obstetrics and Gynecology and Female Pelvic Medicine and Reconstructive Surgery.
Dr. Matthew Harris, MD
Medical Director of Pediatric Orthopedics and Outpatient Rehabilitation Services at Jupiter Medical Center
Dr. Matthew Harris, MD works in Jupiter, FL as an orthopedic surgery specialist. He is board certified in orthopedic surgeryand graduated from STATE UNIVERSITY OF NEW YORK AT BUFFALO / SCHOOL OF DENTAL MEDICINE. Dr. Harris has has worked on more claims relating to femur fracture than other providers.
Zachary McVicker
Fellowship-trained sports medicine physician
Dr. McVicker has served as an assistant team physician for the Los Angeles Rams, Los Angeles Dodgers, LA Galaxy, LA Football Club (LAFC), as well as the University of Southern California (USC) football team and the Miami Marlins. Dr. McVicker currently practices at the world renowned Paley Orthopedic and Spine Institute in West Palm Beach, Florida. He helped to create and direct the Sports Medicine program at the Paley Institute. Dr. McVicker prides himself on treating the entire patient to facilitate the physical and mental well-being required to return to an active lifestyle.
Dr. Ari Yoder
Licensed Optometrist
Dr. Yoder graduated from The Ohio State University College of Optometry in 2012. He currently is a partner and practices in a multi location optometry practice in the middle of Amish country Ohio. Implementation of a proactive approach to eye health has been essential for Dr. Yoder in serving his patients, specifically those with diabetes.
Dr. Shahnoz Rustamova
Obstetrics & Gynecology
Dr. Rustamova graduated from the Samarkand State Medical Institute in 1995. She works in New York, NY and Jupiter, Fl, and specializes in Obstetrics & Gynecology. Dr. Rustamova is affiliated with Mount Sinai St Luke’s Hospital.
Dr. Ronald Gazze
Executive Medical Director NextEra Energy/ FPL
Where he is responsible for providing primary care and coordinating other medical care for many of the corporation’s leaders and other team members with complex cases. He is also the corporate medical subject matter expert, including for the pandemic team.
Townley Peters, Psy.D, RYT
Licensed Clinical Psychologist in Florida and Bermuda
Townley Peters brings a wealth of expertise to Vell Health’s Mind/Body program, drawing from her extensive background as a psychologist committed to empowering individuals. Grounded in the belief that every person is inherently complex, Townley’s approach emphasizes collaboration and genuine care. Her professional demeanor is complemented by a human touch, ensuring a supportive and comfortable environment for those seeking growth and change.
Dr. Richard Zonderman
Licensed Psychologist
Associate Professor at Albizu University- Industrial/Organizational Psychology and Counseling programs.

Candidate screening for the Miami Dade College School of Justice Police Academy and local police departments.

Member of the Florida Psychological Association and the International Association of Chiefs of Police Psychological Services section.
Russell Bourne, Jr., Ph.d.
(University of Virginia) Clinical psychologist on staff at Jupiter Medical Center
Former President Florida Psychological Association, Currently on the Legislative Affairs and Public Policy Board.

Former associate Dean Randolph-Macon College and The University of Virginia.

Former President of the Virginia Ericksonian Institute, Consultant to the Florida and Virginia Judicial Systems, municipal law enforcement departments as well as to various businesses and the media. Central Intelligence Agency for 24 years.
Bill Reichel
President at Reichel Realty & Investments, Inc.
Bill has deep expertise and a proven track record in virtually every facet of Florida commercial real estate — leasing, management, brokerage, receivership and workout of commercial properties throughout the state. He also has extensive experience in construction, development management services and real estate tax appeal work.

Since its inception in 1987, Reichel Realty has facilitated thousands of commercial transactions totaling over $2 billion of gross business volume.
John Mattessich
Chief Financial Officer Maroone USA
With over 20 years of extensive experience in procurement and purchasing, John brings a wealth of knowledge and expertise to our Executive Advisory Board.

John’s impressive journey began in 1996 at Mars Snackfoods, USA, where he served as a Commodity Manager. His dedication and passion for the field led him to Florida Crystals, where he took on roles of increasing responsibility, ultimately becoming the Vice President of Procurement in 2015.

We’re excited to have John on board as we continue our mission to elevate and innovate in the world of holistic health and wellness. Join us in welcoming John Mattessich to the Vell team!
John Hoctor
Chief Financial Officer Maroone USA
John Hoctor, the Chief Financial Officer at Maroone USA, has consistently demonstrated remarkable financial expertise and leadership skills. His extensive experience in financial management contributes significantly to Vell Health’s strategic development, showcasing a proven track record of driving financial success in his role as CFO.
Art Mandell
Director, MaxCyte Inc. Former Pharmaceutical & Biotech CEO
Art Mandell, serving as Director at MaxCyte Inc., is a distinguished figure with a rich background in the pharmaceutical and biotech industries. As a former CEO in the pharmaceutical and biotech sector, Art has showcased outstanding leadership acumen and strategic brilliance.

His contributions to the field have been marked by a commitment to innovation, driving growth, and ensuring the advancement of cutting-edge technologies. With a deep understanding of the intricacies of the pharmaceutical and biotech landscapes, Art Mandell continues to play a crucial role in shaping the trajectory of VELL Health.
Marshall Warner
VP Chesapeake Bank
Marshall Warner, a seasoned banking professional, has made significant contributions during his tenure as Executive Vice President at Chesapeake Bank. With a wealth of experience in the financial sector, Marshall demonstrated exceptional leadership, strategic vision, and a commitment to excellence.

His role involved overseeing critical aspects of the bank’s operations, contributing to its growth, and ensuring the delivery of high-quality financial services to clients. Marshall’s dedication to the banking industry has left a lasting impact on Chesapeake Bank and the broader financial community.
Ann Pace

Head of Legal, USA, World Gold Council

Ann Pace serves as the Head of Legal, USA at the World Gold Council, bringing extensive legal expertise to the organization. With a robust background in legal affairs, she plays a pivotal role in navigating the legal landscape for the World Gold Council in the United States. Ann’s leadership and legal acumen contribute significantly to the organization’s success in the dynamic gold industry.
Russell Bourne, Jr., Ph.d.
Clinical Psychologist
Since 2006, Dr. Bourne has played a crucial role at Jupiter Medical Center, contributing to the Medical Ethics Committee. As a licensed psychologist in Florida and Virginia, he brings a wealth of experience to Vell Health.

Dr. Bourne’s leadership goes beyond clinical practice; he was President of the Florida Psychological Association, Palm Chapter, and actively engages in legislative affairs. With a rich academic background and extensive consultancy work, including 24 years with the CIA, Dr. Bourne’s knowledge is a driving force in shaping Vell Health’s future.
Robecca Quammen
2nd Founder, HealthITq and Quammen Group
Robecca is a forward-thinking industry leader with a results-oriented approach, acknowledged as a champion for healthcare transformation through innovative information technology solutions. With a 30-year career in healthcare, she has held senior management roles in large provider organizations, the nation’s largest healthcare software vendor, and prominent healthcare consulting practices.

Renowned for spearheading organizational change initiatives, Robecca is committed to enhancing clinical care delivery and improving the bottom line in the ever-evolving healthcare landscape.
Michael Viola

Chief Executive Officer (CEO) at Congruity HR

After more than 25 years in the Professional Employer Organization (PEO) space, Mike brings deep domain expertise and a proven track record to his role as CEO of Congruity HR.

As co-founder and Chief Sales Officer for Oasis Outsourcing, Mike and his team quickly grew Oasis into the largest privately held PEO in the United States, ultimately serving 9,000 clients and 300,000 worksite employees across all 50 states.

After Paychex acquired Oasis in 2018, Mike was an Advisory Partner in the Private Equity space and served on several boards until joining Congruity as its CEO.
Dave Frisbie
MBA from Harvard
As a Vice President of Hines Interests during the 1980’s he managed major downtown revitalization projects including I. M. Pei’s JP Morgan Chase Tower (the tallest 5-sided building in the world), Cesar Pelli’s Wells Fargo Center, and Philip Johnson’s One Detroit Center (the tallest office building in Michigan). He was also one of the leading visionaries to participate in the redevelopment of downtown West Palm Beach.

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